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Abstract The phosphoinositide 3-kinase (PI3K)Akt axis is one of the most frequently activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal cancer (CRC)

Statistical analysis All results are presented as means SEM

doi: 10.4049/jimmunol.1301859 40 ShiLZWangRHuangGVogelPNealeGGreenDRet al

Lerner AJ, Arnold SE, Maxfield E, Koenig A, Toth ME, Fortin B, Mast N, Trombetta BA, Denker J, Pieper AA, Tatsuoka C, Raghupathy S, Pikuleva IA (2022) CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimers disease

Such clinical findings were confirmed in vitro , with oxidative stress identified to be partially involved in NLRP3-mediated IL-1 secretion by monocyte cultures exposed to SARS-CoV-2