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Besides, saikosaponin A activates IL-12/STAT4 pathway to increase serum IFN- and IL-12 levels and decreases in serum IL-4 and IL-10 levels, which shift Th1/Th2 balance toward Th1 [259]

With time, these alterations can induce mitochondrial dysfunction, facilitating cell death mechanisms like ferroptosis

Vitamin E (tocopherols)Stabilizes membranes against lipid peroxidation

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