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SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity

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doi: 10.1093/cid/ciz1001 7 RamendraRIsnardSMehrajVChenJZhangYFinkelmanMet al

The neutrophils role during health and disease

Lung ischemia reperfusion injury was induced by applying a microvascular clamp to the left lung hilum of mice for 1 h, followed by release of the clamp for reperfusion, as previously described [21]