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We would like to acknowledge Advanced Microscopy and Imaging, Bioinformatics, High Content Screening, and Advanced Histophatology cores of TIGEM for help with data acquisition and analysis, Cathal Wilson (TIGEM) for critical reading of the manuscript, Annamaria Carissimo for bioinformatics support, Luca DOrsi, Veronica Maffia and Edoardo Nusco (TIGEM) for technical help, Ines Mancini (University of Trento) for providing SM875

There were 5 patients per cohort in Part B, with the exception of the 0.1 mg/kg ImmTOR + 0.4 mg/kg pegadricase group for which an additional 5 patients were added under a protocol revision to increase the N, as these patients showed a heterogenous effect of ImmTOR on anti-uricase IgG responses and maintenance of low sUA