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By directly increasing the production of angiotensin II (Ang II), hyperglycemia causes EndMT in primary human aortic endothelial cells, which damages the endothelium (45)

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Glutathione is synthesized in the cytosol of each cell by the action of two enzymes in an elegantly regulated system that allows it to be maintained at different homeostatic levels in different tissue types, with the liver, given its detoxification role, having the highest amounts