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The pharmacodynamic studies have demonstrated superior antiarthritic activity of DSP-NPs compared to marketed formulations in the AIA rat model [61]

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Additionally, research has indicated that melatonin may be relatively ineffective, potentially due to treatment periods being either too brief or too prolonged

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Figure 4 schematically shows potential consequences of acute intense exercises, unhealthy diet (e.g., high-fat diet), and dysbiosis on the intestinal barrier