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40 MANAGEMENT OF PRIMARY SCLEROSING CHOLANGITIS Medical Management No single drug or treatment has been proven to prolong transplant-free survival in PSC

When mitochondrial damage accumulates above a certain threshold, for example in response to energy deprivation, OS, or hypoxia, cells activate a mechanism to selectively target and remove damaged mitochondria via the autophagic machinery to renew the mitochondrial pool (231)