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Moreover, peroxynitrite has been implicated in the nitration of the EAAC1 neuronal transporters, reducing the cells ability to take up cysteine and inhibiting the intracellular neuronal production of the endogenous antioxidant glutathione, which can also lead to cell death due to the inability to counter intracellular oxidative stress (McElroy et al., 2017)

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Long-term oral administration of an HNF4 agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function

Discordant research findings may be attributed to varied research methodologies and characteristics of the control group, including differences in age, sex, and socioeconomic factors