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Although the epidemiology and clinical prevalence of NeP in SCI and DCM have been well described, the mechanisms underlying their persistence and heterogeneity remain unclear

Mentioned reactive aldehydes, as well as isoprostanes, particularly F2-isoprostanes, are bioactive compounds formed via nonenzymatic peroxidation of arachidonic acid (AA), serving as reliable biomarkers for assessing oxidative stress status in various clinical conditions 89

Biochem J 1997

Calcification causes blood vessels to harden and thicken, which means the heart has to work harder to pump blood around the body

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