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As damage accumulates with age and NAD+ falls, repair capacity is compromised (Fang et al., 2017)

Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study

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In this case, antigen processing within antigen presenting cells to generate peptide sequences is not needed for T-cell activation as peptides are displayed naturally by surface MHC molecules