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Thus aqueous solutions of small, highly charged metal ions, such as Al 3+ and Fe 3+ , are acidic: Equation 16.36 The [Al(H 2 O) 6 ] 3+ ion has a p K a of 5.0, making it almost as strong an acid as acetic acid

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Subsequent studies have further illuminated the critical importance of glutamine availability, showing that a reduction in c-MYC protein levels, which leads to diminished cellular proliferation and impaired NK cell function, results primarily from glutamine scarcity rather than the direct inhibition of glutaminolysis [127]