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doi: 10.1016/j.ymthe.2019.05.024

The GH axis contributes to sleep architecture, cognitive function, energy metabolism, skin integrity, and mood regulation, all of which shift during perimenopause

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The novel SIRT1 activator SRT2104 may offer protection against diabetic nephropathy by modulating the SIRT1/P53/NRF2 axis, thereby enhancing renal antioxidant activity in diabetic conditions [69]