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In the preclinical literature it is studied primarily as a cytoprotective and angiogenic agent, meaning research examines how it may influence the survival of cells under stress and the formation of new blood vessels in laboratory models

It is believed that local tissue hypoxia may be the underlying pathophysiology by which age, genetics, and androgens interact to cause baldness

doi: 10.1038/ncb3039 138 DupuyFTabariesSAndrzejewskiSDongZBlagihJAnnisMGet al

BPC-157 Investigational peptide noted for promoting tissue healing and reducing inflammation in preclinical models

SIRT1 acts on the pathway of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) (Tang, 2016), a fundamental regulator of energy metabolism (Thirupathi and de Souza, 2017) and mitochondrial dynamics (Singh et al., 2016) associated with an increase in antioxidant defenses through SOD2 and GSH (Liang and Ward, 2006