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Heavier individuals with more adipose tissue often benefit from doses at the higher end of the standard range (450-500mcg)

Vitamin B12: Benefits, Functions & What It Does Vitamin B12, or cobalamin, is a vital water-soluble vitamin essential for red blood cell formation, neurological health, and DNA synthesis

3 Further in vitro studies are needed to refine aspects such as tissue-specific targeting, metabolic stability, and elimination, with the aim of maximizing clinical potential and minimizing off-target effects

(More information) Vitamin B 12 deficiency is commonly associated with chronic stomach inflammation, which may contribute to an autoimmune vitamin B 12 malabsorption syndrome called pernicious anemia and to a food-bound vitamin B 12 malabsorption syndrome