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Research has shown that superoxide, a reactive oxygen species, optimizes force production in skeletal muscle ( Present perspectives Although recent publications from authors such as First, NO may affect contractile function via its involvement at the neuromuscular junction (Wildemann and Bicker, 1999), enhances neurotransmitter release ( It is well-established that NO regulates intracellular calcium via ryanodine receptor activation and sarco/endoplasmic reticulum calcium ATPase pump inhibition ( NO and mitochondria Role of NO in mitochondrial biogenesis Although the underlying mechanisms are not fully understood, several studies indicate an interaction between NO and a mitochondrial biogenesis regulator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1) (Figure 3)

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10.1186/s41983-022-00452-2 Egypt J Neurol Psychiatry Neurosurg