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Pharmacological management Carbonic anhydrase inhibitors: acetazolamide and methazolamide Acetazolamide: Currently, acetazolamide treatment is considered one of the most effective pharmacological strategies for CMS treatment

Another temophen-supported nanodrug delivery system (VES-CSO/TPGS-RGD) has been shown in colorectal cancer to promote PD-L1 expression via HIF-1 and synergistically increase DCs maturation and ICD with PD-L1 blocking (137)

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