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APOE4 Causes Widespread Molecular and Cellular Alterations Associated With Alzheimer's Disease Phenotypes in Human iPSCDerived Brain Cell Types. Neuron 98: 11411154.e1147

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5 Limitations and future directions of research Given the scope of the present study, several key factors warrant acknowledgment: First, bridging the translational gap between animal models and human clinical applications is challenging

The slow titration schedule described in the dosing section is specifically designed to minimize these effects

However, the synthesis of highly selective or isoform-specific inhibitors that reduce unwanted side effects still remains challenging