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JAK pathway targeting presents therapeutic potential for addressing SASP-mediated inflammation and frailty in aging populations (422), driving research into SASP-modulating therapeutic approaches including senolytic and senomorphic compounds (423)

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

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Safety Considerations and When Provider Guidance Is Essential Glutathione is generally well-tolerated, but excessive supplementation may cause gastrointestinal upset, headaches, or rarely allergic reactions