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Yamawaki et al., 2022

Learn 72 , 247262 (2008)

Acetaminophen is metabolized in the liver by conjugation with sulfate and glucoronidate

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Consequently, pro-caspase-1 self-cleavage produces the activated caspase-1, which in turn cleaves gasdermin-D (GSDMD), and the N-terminal GSDMD fragments finally form pores into the plasma membrane through which inflammatory mediators are released, among which IL-1 and IL-18 (Franchi et al., 2009