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Although meta-analyses demonstrate survival benefits from autophagy inhibitor treatment, sample sizes remain limited and most are early-phase trials [158]

A depletion in NAD + results in bioenergetic failure of mitochondria and eventually cell death 90,91

In skincare, it's used topically to help support the skin's defense against oxidative stress caused by sun exposure, pollution, and everyday environmental damage

doi: 10.1126/science.1242454 22 GeltinkRIKKyleRLPearceEL