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In this cell line glutamate induced cytotoxicity could be mediated by oxidative stress through CySS/glutamate antiporter, depletion of GSH, down regulation of SOD activity leading to apoptosis (oxidative glutamate toxicity

In July, the company filed a complaint about a cyber attack

Oct 2016;38(10):2277-2285

The experiments conformed to UK Home Office regulations under the Animals (Scientific Procedures) Act 1986, including Amendment Regulations 2012, and adhered to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines

Initially used to treat rheumatoid arthritis and multiple sclerosis, DHODH inhibitors were later found helpful in treating cancer, viral infections, and blood disorders [55,56,57,58]