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A microemulsion combining a bifunctional AS1411 aptamer/hyaluronic acid co-delivering shikonin and docetaxel (AS1411/SKN&DTX-M) was developed for targeted therapy of glioma, successfully crossing the blood-brain barrier, enhancing drug delivery and cytotoxic effect, blocking cancer stem cell spheroid development, and significantly lowering glioma growth, offering a potential strategy for combined antiglioma treatment [146]

A 2016 animal study in the International Journal of Biological Sciences revealed that hydrogen water administration increased the activity of both SOD and glutathione peroxidase in radiation-exposed mice, suggesting improved functionality of both mineral-dependent enzyme systems

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Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gi protein/MAPK/MMP9 intracellular signaling