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Depending on the chemotherapy regimen, severe CIPN (i.e., symptoms that limit self-care activities of daily life or are life threatening), classified as grade 3 or 4, can occur in up to 35% of patients and symptoms can be so bothersome that they force dose-modifications or treatment discontinuation (Lustberg 2024

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Ethics declarations Competing interests The authors declare the following competing interests: T.M

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function