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The protective effect is to reduce BLM-induced oxidative stress and pulmonary inflammation by regulating the inflammatory response of rat alveolar macrophages (Liu et al., 2017b)

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Neutrophils are normally recruited by chemokines released by tumors, and tumor-associated neutrophils (TANs) promote CD8 + T cells responses and anti-tumor activity in the absence of tumor-derived TGF-, whereas in the presence of TGF- promotes the tumor-promoting activity of CD8 + T cells [104]

In naturally aged mice, FOXO4-DRI treatment improved multiple healthspan parameters including physical activity, kidney function, and fur quality