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Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation

2nd Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice

Typically, this has been carried out either through the use of error-prone PCR (as described in Moore, J., et al, Nature Biotechnology 14:458, (1996), or through the application of randomized synthetic oligonucleotides corresponding to specific regions of interest (as described by Derbyshire, K

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