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Specifically, in addition to anti-thyroid stimulating hormone receptor (TSH-R), Abs have also been found to target insulin-like growth factor 1 receptor on orbital fibroblasts [155], which results in the synthesis of hyaluronan and secretion of interleukin (IL)-1 to IL-16, effectively recruiting autoreactive T cells [156]

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Still, when dealing with dogs that cannot be handled with with the help of standard medications, when facing slow-healing wounds, inflammatory diseases, and cases that could not respond well to the traditional medicines, it is still an interesting option, which needs to be carefully considered

Claudin-2 regulates colorectal inflammation via myosin light chain kinase-dependent signaling