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Class IV drugs (low solubility/low permeability) are poorly absorbed orally owing to both solubility and permeability limitations

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Selective modulation of the nitric oxide system balances beneficial vasodilation against inflammatory damage, creating optimal healing conditions

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[DOI] [PMC free article] [PubMed] [Google Scholar] Eijkelenboom A, Burgering BM

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2015 Feb;125:26-46

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