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Location patterns differ significantly: oral and genital areas are most common for viral lesions, while acne predominantly affects the T-zone (forehead, nose, chin) and can appear anywhere with oil glands

Design and characterization of 4D-710, an aerosolized gene therapy for cystic fibrosis lung disease

10.1073/pnas.1613121113 85

& Hefti, J

4-HNE remains to be extensively studied in lung injury, but recent reports show that 4-HNE forms adducts with multiple mitochondrial targets, which ultimately results in mitochondrial dysfunction and disruption of cellular bioenergetics (20)