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Standard workplace drug screens do not look for peptides

Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets

However, for glutamate export to occur cystine import is mandatory, thus the increased intracellular levels of cysteine must be relevant for cancer poor prognosis

[DOI] [PubMed] [Google Scholar] 93.Solomon B, Varella-Garcia M & Camidge DR ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer

Despite advancements in metabolomics, which reveal changes in metabolites, a deeper understanding of the biological mechanisms behind these changes and metabolic regulatory processes is still lacking