clamitans melanota File:Northern Green Frog (Lithobates melanota) (29760682146).jpg Closeup of a Northern Green

This astrocyteneuron redox coupling is highly sensitive to sleep disruption, which alters the brains oxidative state and mitochondrial efficiency

Fibroblasts from IPF-affected lungs demonstrate increased mTOR signaling, which may accelerate fibrosis in part by increasing proliferation and activity of fibroblasts, decreasing their sensitivity to normal down-regulating signals, and inactivating cell-death pathways (Lawrence 2018

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[27] The connection between GSTP inhibition of the pro-apoptotic JNK pathway and the isozyme's overexpression in drug-resistant tumor cells may itself account for the tumor cells' ability to escape apoptosis mediated by drugs that are not substrates of GSTP

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