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The risk of bias in the trial was scored as low

However, under the MDD pathological condition, due to the decreased expression of EAATs in astrocytes, excessive glutamate in the synaptic cleft activates synaptic mGluRs, which leads to neuronal excitotoxicity

doi: 10.1021/acsptsci.2c00212

J Biol Chem (2001) 276:210838.10.1074/jbc.M101836200 50 GargADKryskoDVVerfaillieTKaczmarekAFerreiraGBMarysaelTet alA novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death