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A human clinical trial began in 2015

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Ethics declarations Competing interests During the past 3 years, the author has been a consultant for Bristol Myers Squibb, GSK, Mozart Therapeutics, Ono Pharmaceutical, Precigen ActoBio, Sanofi, SQZ Biotech, Takeda and Topas Therapeutics

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Semel et al., Adaptive behavior was assessed using the Vineland Adaptive Behavior Scales, 2nd Edition, Interview Edition, Survey Form (VABS), an instrument that has demonstrated good reliability and validity (Sparrow et al., The Aberrant Behavior Checklist (ABC) was designed to measure disruptive behaviors in individuals with developmental disabilities (Aman et al., The Social Responsiveness Scale (SRS) measures the severity of social skill deficits (Constantino, Statistical analysis The glm procedure of SAS 9.1 (SAS Institute Inc., Cary, NC) was used with a two-tailed alpha of 0.05