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10.1007/s11064-013-1157-2 31 HanrahanJ

Even if a fraction of the active ingredient reaches the small intestine intact, its absorption is often severely restricted due to unfavorable molecular size, poor intestinal permeability, and extensive hepatic first-pass metabolism

Pignocchi C, Foyer CH (2003) Apoplastic ascorbate metabolism and its role in the regulation of cell signalling

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