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In MELAS, seizures occur with a frequency ranging from 71 to 96% (26), and typically present as generalized tonicclonic seizures, focal seizures, or generalized status epilepticus (27)

Although these mechanisms have been predominantly characterized in non-tumor systems, they provide important conceptual frameworks for understanding the directionality and execution of mitochondrial transfer under metabolic stress

Fillinger S, Boschi-Muller S, Azza S, Dervn E, Branlant G, Aymerich S

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It was originally developed in Australia by Metabolic Pharmaceuticals as an investigational obesity drug and is also called HGH Fragment 176-191