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However, the efficacy of this combination therapy has received limited success in vivo due to the poor oral bioavailability and short half-life of butyrate (345)

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1460-C BEPIROVIRSEN HAS INTRINSIC INNATE ACTIVITY, DISTINCT FROM THAT OF OTHER ANTI-SENSE OLIGONUCLEOTIDES Megan Ermler 1 , Kristen Jones 1 , Amitabh Das 1 , Anne DeHart 1 , Nicholas Galwey 1 , Melanie Paff 2 and Shihyun You 2 , (1)GSK, (2)GSK, Collegeville, PA, USA Background: Bepirovirsen (BPV) is an anti-sense oligonucleotide (ASO) that is in phase 3 clinical trials for chronic hepatitis B (CHB)