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Description

Rodent (lean diet combination) Sampson et al

Reading about peptides is one thing

5-Amino-1MQ is a small-molecule NNMT inhibitor

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Kraus NA, Ehebauer F, Zapp B, Rudolphi B, Kraus BJ, Kraus D

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects