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Early CagriSema trials show weight loss that matches or exceeds these results at comparable time points

Abnormal estrogen signaling through ER is a major driver of tumorigenesis in luminal A and luminal B breast cancers [4], as it promotes the proliferation of cancer cells by overexpressing cyclin D1 and c-Myc, both of which enable the tumors to bypass the G1/S checkpoint [5]

Marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight management), tirzepatide has demonstrated significant efficacy in randomized clinical trials

These included gastrointestinal lesions, pancreatic injury, hepatic damage, cardiac tissue impairment, endothelial disruption, and alterations in vascular pressure regulation

Rev Physiol Biochem Pharmacol 136:183223 Rights and permissions Copyright information 2004 Springer-Verlag About this entry Cite this entry (2004)