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Autophagy revisited: a conversation with Christian de Duve

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7 Early treatment for PANDAS is ideal because it can minimize future relapses, which can increase the duration and intensity of symptoms down the road

Unlike the macrophages and neutrophils that predominate in fibrosis-associated leukocyte infiltrates, DCs express the PDPN ligand CLEC-2, which decouples PDPN from ezrin and inhibits fibroblast contraction