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Ferroptosis-inducing drugs used for tumor treatment Inhibition of the System XC- activity The main function of System X C - is to transfer glutamate from inside the cell to the outside and transfer the extracellular cystine into the cell, and the transferred cystine is used for the synthesis of glutathione in the cell

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doi: 10.26355/eurrev_202102_25077 223 TgelFWeissKYangYHuZZhangPWestenfelderC

Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X (2023) PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinsons disease in diabetic rats