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[] The long-time of the liver qi depression will transform into fire, the enhanced fire will further consume the yin-jin () of the human body, and then, yin fails to control yang due to the deficiency of yin fluid, thus resulting in hyperactivity of the liver yang (), which is characterized by headache and dizziness

397,398 The KAITLIN phase 3 study compared anthracycline-based chemotherapy and then 18 cycles of T-DM1 plus pertuzumab (AC-KP) to taxane (threefour cycles) plus trastuzumab plus pertuzumab (AC-THP), adjuvant AC-KP did not result in statistically significant or clinically meaningful improvement in iDFS compared with AC-THP in patients with high-risk early breast cancer