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Mechanism of mitophagy BNIP3 and NIX BNIP3 and BNIP3-like protein (BNIP3L)/Nip3-like protein X (NIX), members of the BCL2 family of BH3-only domain proteins, are localized to the OMM and function as pro-apoptotic proteins

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While no direct contraindication exists for concurrent use, the absence of controlled trials means safety and efficacy remain inadequately characterized