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Under Localis-REX conditions, cells were exposed to light (2 minutes, 5 mW cm 2 , 365 nm), the conditions for all the controls were shown below

Cross-trial inference

Mechanistically, IL-23 signaling through its heterodimeric receptor (IL-23R/IL-12R1) activates STAT3 phosphorylation (pSTAT3), which drive their commitment to a Th17-like pathogenic subseta process critical for the production of IL-17A and IL-22 (126), which in turn enhance epithelial permeability and inflammatory infiltration in the gut (127)

The kidneys suffer similar fates: heavy metal contaminants like mercury muck up their filtering capacity, eventually leading to chronic kidney disease when exposed to such overloads