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For acute ischemic stroke (AIS) cases, the use of IV recombinant Tissue Plasminogen Activator (IV-rTPA) significantly improves outcome and decrease long-term disability

Compared with the other two silica nanomaterials, solid silica nanoparticles upregulated the expression of LC3-II through ERK1/2 and AKT/mTOR signaling pathways, activated the autophagic flux of MSCs, and enhanced osteogenic differentiation potential

Another potential mechanism of action for the pain-reducing properties of vitamin B12 comes from interactions with prostaglandin synthesis, including cyclooxygenase (COX) enzymes