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Nature (2009) 458(7239):7625

In addition, some reports have shown that the expression of ADH I gene is regulated by sex hormones, which elevated level is noted at women who consume ethanol, what also can be associated with carcinogenesis in uterus [53]

Therefore, the lactide rich PLGA (i.e., copolymer of PLA and PGA) is almost hydrophobic (Makadia and Siegel, 2011) and poorly soluble in polar solvents such as acetic acid (i.e., the solvent of PEO-CS solution)