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The immediate concern is protocol consistency

10.1186/1476-069X-4-25 122

A., Jackson, J

6 Conclusions IGF-1 has numerous beneficial and protective effects on the CV system, including anti-apoptotic and pro-survival effects on cardiomyocytes and vascular bed cells, tissue remodeling effects, cardiac development and contractility stimulation, vasodilation and decreased vasoconstriction