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Figure 1 Vitamin B12 deficiency, defined as ciculatory B12 level below 150200 pg/mL (borderline 200300 pg/mL) (8), is a significant global health concern, particularly affecting the elderly (9, 10), pregnant women (11), and young children (12), especially in regions with limited dietary options

This results in a complete lack of pigmentation in skin, hair, and eyes

Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term

Role of the tight junction in the stomach and related diseases In the stomach, the tight junctions formed by adjacent gastric epithelial cells play a pivotal role in regulating the paracellular permeability of ions, nutrients, and other solutes and preventing digestive enzymes and toxins for entering the systemic circulation

Anatomy and Physiology 18.4 Hemostasis