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doi: 10.1016/j.plefa.2003.11.001 17

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Radiotherapy inhibits tumor growth by generally inducing tumor cell apoptosis, senescence, autophagy, necrosis, or mitotic catastrophe through inflicting extensive DNA damages (Valenciano et al., 2012

Our findings are in line with other reports showing a decrease in Sirt6 protein expression in transgenic mice (5XFAD) 133 as well as decreased gene and protein expression in AD patients 133,134