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doi: 10.1007/BF00191904 139 LocheSCambiasoPMerolaBColaoAFaeddaAImbimboBPet al

DHODH in the inner mitochondrial membrane inhibits lipid peroxidation in the mitochondria by reducing CoQ 10 to CoQ 10 H 2 , indicating that DHODH can be a novel therapeutic target in cancer therapy by inducing ferroptosis

Threonine sensing: Similar to the role of LARS in leucine signaling, threonine levels regulate mTORC1 via TARS2 (mitochondrial threonyl-tRNA synthetase 2)

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Abstract In contrast to the multiple disease-modifying therapies that are available for relapsingremitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are limited