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In a randomized controlled trial in patients with celiac disease, acute gluten exposure caused a 70% increase in intestinal permeability in the placebo group, while no change in permeability was seen in the larazotide group

Its amino acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val is freely soluble in water, making reconstitution straightforward for laboratory use

25 Furthermore, many patients with POTS have associated generalized symptoms including fatigue, malaise, sleep disruption, headache and gastrointestinal symptoms, features often observed in chronic autoimmune disease

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