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In older people, there may not be sufficient stomach acid to start the breakdown process

If you have a medical condition or give blood on a regular basis, that number can climb rapidly

In the ATTAIN-1 Phase 3 trial, the most frequently reported adverse events with orforglipron 36 mg versus placebo were nausea (33.7% vs 10.4%), constipation (25.4% vs 9.3%), diarrhea (23.1% vs 9.6%), and vomiting (24.0% vs 4.0%)